Marine Peptides Attenuate Oxidative Stress to Manage Diabetes And Diabetes- Related Parameters

Author: Md Atiar Rahman
DOI: doi.org/10.70279/bmj-v5-i2-1020
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An increasing prevalence of diabetes, in the last few decades, is known as a main risk for human health worldwide. Due to patience’s inconvenience, unaffordability and adverse effects of synthetic drugs, a large number of diabetic patients are in search of alternative therapeutics while marine products have been placed at the top. Marine peptides, among all marine products, are highly impactful due to their bioactive properties as potential nutraceutical and effective therapeutics. Therefore, this review has focused on the marine bioactive products having antioxidative effects leading to attenuate diabetes and diabetes-related complications. The manuscript also tried to understand the underlying mechanism for antidiabetic actions showed by the marine products especially marine peptides. A systematic literature review has been undergone to collect the relevant data on the said issue using authentic portals for biological and medical journals which displayed marine peptides and their derivatives having high antidiabetic effects, commercial values, wider pharmaceutical and nutraceutical markets. Recent advances in the understanding of the effect of marine products explored their antioxidative potentials, regulation on glucose metabolism (including insulin-regulated glucose metabolism), enhancing glucose-stimulated insulin secretion and inhibition α-amylase activities. A large number of them are already in different phases of the clinical and preclinical pipeline. This review showcases the trends and prospects of marine products in the management of diabetes and diabetes-related complications for the future with special emphasis on mechanistic approach.